대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Non-Albumin Proteinuria (NAP): An Accessible, Affordable, and Easy-to-Use Biomarker for Predicting Acute Kidney Injury in Acute heart failure (NAP-HF study)
저자	Solos Jaturapisanukul
출판정보	2024; 2024(1):
키워드
초록	Objectives: Identifying acute kidney injury (AKI) early in acute heart failure (AHF) patients remains challenging, many urine biomarkers are costly and inaccessible. This study focuses on non-albumin proteinuria (NAP), calculated as Urine Protein-to-Creatinine Ratio (PCR) minus Urine Albumin-to-Creatinine Ratio (ACR), to evaluate its effectiveness in predicting AKI in AHF patients. Methods: In this prospective study, we evaluated 74 adults admitted with AHF to determine if NAP at the time of AHF diagnosis could predict AKI within 7 days. We also monitored changes in serum creatinine from baseline at day 2, day 7 and day 28. Exclusion criteria were a UPCR greater than 3, presence of pyuria or hematuria, chronic kidney disease (CKD) stage 5, or prior kidney replacement therapy. Results: In this study of 74 AHF patients, the incidence of AKI was 14 cases (23.61%). The levels of NAP at admission were significantly higher in patients who developed AKI (0.53 vs 0.22, p < 0.001). Furthermore, a NAP value greater than 0.3 was significantly associated with AKI development by day 2 (57.7% vs 10.9%, p < 0.001), by day 7 (50% vs 2.2%, p < 0.001), and with acute kidney disease (AKD) by day 28 (61.5% vs 6.5%, p < 0.001). Univariable analysis indicated that the lack of atrial fibrillation, beta-blocker therapy, lower hemoglobin (Hb) levels, elevated blood urea nitrogen (BUN), and NAP > 0.3 were linked to AKI. Multivariate analysis identified lower Hb and NAP > 0.3 as significant predictors of AKI in AHF patients, with NAP > 0.3 showing a odds ratio (OR) of 39.5 (p < 0.001). Conclusions: An increase in NAP indicative of tubular protein damage correlates with the development of AKI in patients with AHF. Consequently, NAP shows potential as an effective, affordable, and easily accessible tool for predicting AKI in the AHF patient population.
원문(PDF)	PDF 원문보기

목록

위로가기