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논문분류	춘계학술대회 초록집
제목	Association Between Early Smoking and Cardio-cerebrovascular Diseases in Chronic Kidney Disease: A Nationwide Population-Based Study
저자	Sehyun Jung
출판정보	2024; 2024(1):
키워드
초록	Objectives: Smoking initiation at the young age is associated with elevated risk of mortality. Additionally, chronic kidney disease (CKD) is known to increase the risk of both cardiovascular and cerebrovascular diseases. The present study examined the risk of all-cause and cardio-cerebrovascular disease-specific mortality based on the age of smoking initiation and the intensity of smoking, among the patients with CKD. Methods: The study included participants aged 20 and above, who received the national health screening examination in 2009 and were diagnosed with CKD. The primary outcome was the occurrence of myocardial infarction (MI), stroke, and all-cause mortality. To compare the risk of adverse events according to the initiation age and the intensity of smoking, we categorized the ratio of pack year and the smoking age into quartiles. Cox regression analysis was used to explore the association with the outcomes. Results: Overall, 652,223 participants were included in the study. The smoking group had the highest number of individuals who started smoking at the age of 20 or older with less than 20 pack years. According to the four categories of the intensity and initiation age of smoking, the incidence rates and hazard ratios of the cardio-cerebrovascular disease-caused deaths and all-cause deaths are shown in Table 1. Q4 group; the group with the highest pack year/smoking age ratio exhibited the highest rates of cardio-cerebrovascular and all-cause death. The probability of MI or stroke, and all-cause deaths increased with the increase of the pack year/smoking age ratio quartiles. (Figure 1). Conclusions: The present demonstrated that in patients with CKD, those who started smoking at the early age and had high smoking intensity exhibited elevated risk of cardio-cerebrovascular and all-cause mortality. Earlier quitting of smoking may be beneficial to minimize the risk of cardio-cerebrovascular death among CKD patients.
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