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논문분류	춘계학술대회 초록집
제목	Comparison of Conventional and High-Dose Continuous Kidney Replacement Therapy in Critically Ill Patients with Septic Acute Kidney Injury
저자	Jeehyun Heo
출판정보	2024; 2024(1):
키워드
초록	Objectives: Although prospective studies have suggested no differences in patient outcomes between high-dose and conventional-dose continuous kidney replacement therapy (CKRT) in critically ill patients undergoing CKRT, real world data are lacking. This study aimed to compare patient outcomes between conventional and high-dose CKRT in critically ill patients with septic acute kidney injury (AKI). Methods: This multi-center, retrospective, observational cohort study included 1,390 critically ill patients with septic AKI treated with either conventional (<35 mL/kg/h; n =552) or high-dose (≥35 mL/kg/h; n = 838) CKRT. The primary outcome was 28-day mortality. Secondary outcomes included 90-day mortality, CKRT duration, kidney replacement therapy (KRT) dependence at discharge, and intensive care unit (ICU) and hospital stays. Results: No significant differences were observed for both 28- (52.2% vs. 52.4%, P=0.938) and 90-day (59.8% vs. 61.7%, P=0.475) mortality rates among the conventional and high-dose groups. Compared to the conventional-dose group, the adjusted hazard ratios (95% confidence interval [CI]) for 28- and 90-day mortality were 0.91 (95% CI, 0.78-1.06, P=0.213) and 0.94(95% CI, 0.81-1.08, P=0.383), respectively. The conventional-dose group was associated with both a higher rate of KRT dependence at discharge (17.6% vs. 9.0%, P <0.001) and longer length of ICU stay (median 9.5 vs. 7.0 days, P=0.010), compared to the high-dose group. Conclusions: While mortality rates did not significantly differ, when compared to conventional-dose CKRT, high-dose CKRT appeared to have lower rates of KRT dependence at discharge and shorter lengths of ICU stays.
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