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논문분류	춘계학술대회 초록집
제목	Promoter Genetic Variants Of ELMO-1 rs rs13242914 as risk for Diabetic Kidney Diseases in Jambi Malayan Ethic, Indonesia.
저자	Namira Amanda G
출판정보	2024; 2024(1):
키워드
초록	Objectives: This study was to revealed association of genetic variants of Engulfment and cell motility-1 (ELMO-1) gene with diabetic kidney diseases. In addition to supporting the functional of genetic variants we also measure association of genetic variant and ELMO-1 plasma level Methods: Case control study design was performed with carefully matched of diabetic patients who was suffered DKD (n=43) as case group and who was not suffer DKD (n=31) as control group. Metabolic parameter was measured, DKD diagnose based on albumin creatinine ratio (ACR). ELMO-1 was measure with Enzyme link immune assay (ELISA). Genotyping was performed with Sanger Sequencing Results: Proportion of CT and TT genotype of rs13242914 was higher than CC genotype and statistically significant. In contrary, Proportion subject with GT and TT genotype of rs1882071 and was lower in DKD than GG. Proportion subject with GG was higher and AG was lower of rs13242348 in DKD than AA genotype. Those difference not statistically significant. The three genetic variants not associated with plasma ELMO-1 level (p value 0,670; 0,594; 0,854, respectively). Conclusions: Genetic variants rs13242914 located in ELMO-1 gene promoter associated with diabetic kidney diseases but the ELMO-1 plasma level not differ significantly.
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