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논문분류	춘계학술대회 초록집
제목	Inverse association between serum chloride levels and the risk of atrial fibrillation in chronic kidney disease patients
저자	Yangang Gan
출판정보	2024; 2024(1):
키워드
초록	Objectives: Electrolyte abnormalities are common symptoms of chronic kidney disease (CKD), but the major focus has been on serum potassium and sodium levels. Studies have shown that chloride is an important biomarker for the prognosis of various diseases. However, the relationship between serum chloride levels and incident atrial fibrillation (AF) in CKD patients is unclear. In this study, we sought to determine the association between serum chloride homeostasis and incident AF in CKD patients. Methods: In this retrospective cohort study, we included patients who met the diagnostic criteria for CKD in China between 2000 and 2021. Incident AF was ascertained by ECG assessments in CKD patients. The association between baseline serum chloride concentration and incident AF was determined using Cox proportional hazard models and competing risk analysis. Results: The study cohort comprised 20550 participants. During a median follow-up of 350 days (interquartile range, 123 - 730 days), 211 of the 20550 CKD patients developed AF. According to the fully adjusted models, the serum chloride concentration was inversely associated with the risk of AF after adjustment for demographic variables, CKD-specific factors and cardiovascular and other markers of mineral metabolism (adjusted hazard ratio (HR) per 1-standard deviation greater baseline chloride levels, 0.78; 95% CI: 0.65-0.93). These results were also consistent with those of the competing risk, stratified and sensitivity analyses. Conclusions: In this CKD population, serum chloride levels were independently and inversely associated with the incidence of AF.
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