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논문분류	춘계학술대회 초록집
제목	Association between the number of parity and the prevalence of chronic kidney disease
저자	HeeChan Moon
출판정보	2024; 2024(1):
키워드
초록	Objectives: Pregnancy is associated with abrupt changes in glomerular filtration rate, renal plasma flow, renin-angiotensin-aldosterone system and size of kidneys. It is plausible that these physiologic and anatomic changes could potentially have a long-term impact on kidney. Therefore, this study aims to determine whether the number of parity affects the prevalence of chronic kidney disease (CKD). Methods: We analyzed the health examinee data from the Korean Genome and Epidemiology Study (KoGES-HEXA), which comprises participants from Korea between 2004 and 2013. From 113,937 female subjects, we excluded individuals with histories of gestational diabetes, eclampsia, and pre-existing CKD, as well as participants with incomplete records. Consequentially, 95,608 participants were included in this study. CKD was defined as an estimated glomerular filtration rate below 60 mL/min/1.73 m², calculated using the 2009 CKD-EPI (Epidemiology Collaboration) formula, or the presence of proteinuria. We compared the prevalence of CKD across four groups, categorized by the number of parity; 0, 1, 2, and ≥3. Results: Women with 3 or more parities, compared to those with no parity, were older with more co-morbidities, less likely to smoke or drink, and had higher body mass index, elevated fasting blood sugar and low density lipoprotein cholesterol. Notably, CKD prevalence was higher in women with three or more parities than in no parity group (Table 1). In the univariate logistic regression model, a higher risk of CKD was observed in the ≥3 parity group compared to the 0 parity group (odds ratio: 1.777, 95% confidence interval: 1.271 – 2.486). However, this association was not significant after adjusting for risk factors in the multivariable analyses (Table 2). Conclusions: Despite higher CKD prevalence in women with 3 or more parities, this association disappeared after adjusting for established CKD risk factors, indicating parity may not independently affect CKD risk in Korean women.
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