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논문분류	춘계학술대회 초록집
제목	Assessing the Risk of Poor Renal Outcomes in Taiwanese IgA Nephropathy Patients Using the International IgAN Prediction Tool: a single center retrospective study
저자	Chia-Tien Hsu
출판정보	2024; 2024(1):
키워드
초록	Objectives: IgA nephropathy is the most common primary glomerulonephritis worldwide. To manage IgA nephropathy effectively, identifying high-risk patients is vital. The 2021 KDIGO guidelines recommend the International IgAN Prediction Tool to inform patients but not as a guide to therapy. This study aims to assess the risk of poor renal outcomes in Taiwanese IgA Nephropathy patients using the International IgAN Prediction Tool. Methods: A retrospective analysis of medical records from biopsy-confirmed IgA nephropathy patients at our medical center in Taiwan between January 2010 and December 2020 was conducted. Comprehensive clinical, pathological, and laboratory data were reviewed. The primary outcome was a composite of the first occurrence of either ESRD (eGFR <15 mL/min/1.73m2, dialysis, or transplantation) or areduction in eGFR to below 50% of the value at biopsy. Receiver Operating Characteristic (ROC) curves and the Area Under the Curve (AUC) value were used to assess the predictive performance of the International IgAN Prediction Tool. Results: Our study enrolled 210 patients (49% males, 51% females), with a median age of 40.9 years. At 3 years post-renal biopsy, 33 patients (15.7%) reached the primary endpoint. Table 1 revealed that patients with elevated blood pressure, lower eGFR, increased daily proteinuria, lower serum albumin, and higher predicted risk have poorer renal survival. Figure A demonstrated that patients reaching the primary endpoint had a significantly higher predicted risk score (13.11% vs. 2.21%; p < 0.001). Figure B illustrated an AUC of 0.892 (p < 0.001) for the International IgAN Prediction Tool, with an optimal cut-off value of 3.57% for our cohort. Conclusions: The International IgAN Prediction Tool demonstrated good performance in predicting poor renal outcomes in Taiwanese patients with IgA nephropathy. These findings suggest its utility as a valuable tool for identifying high-risk individuals. However, further research is essential to validate its role as a guide for therapeutic interventions.
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