대한신장학회

논문분류	춘계학술대회 초록집
제목	Maternal Exposure to Fine Particulate Matter Impairs Renal Vascular Homeostasis in Adult Male Rat Offspring: Impact of Maternal Vitamin D Supplementation
저자	Hyung Eun Yim
출판정보	2024; 2024(1):
키워드
초록	Objectives: Maternal exposure to fine particulate matter (PM2.5) during pregnancy has been linked to adverse postnatal health outcomes. In this study, we aimed to investigate the long term effect of maternal exposure to PM2.5 during gestation and lactation on the vascular homeostasis in adult rat offspring kidney. We also evaluated the effect of maternal vitamin D supplementation during fetal rat nephrogenesis on PM2.5-induced renal vascular disturbance in adult rat offspring. Methods: Nine pregnant Sprague–Dawley rats received oral administration of normal saline, PM2.5, or PM2.5 with vitamin D (cholecalciferol 1,000 IU/kg) during gestation and lactation. Kidneys of male offspring (n = 5 for each group) were taken for morphometric, immunohistochemical, and Western blot studies on postnatal day 56. Angiogenic and anti-angiogenic factors were evaluated with the investigation of renal capillary rarefaction. Results: The adult offspring rats exposed to maternal PM2.5 exhibited lower body weight and higher glomerular and tubular injury scores, compared to control rats. Maternal vitamin D supplementation with PM2.5 exposure attenuated these changes. Maternal PM2.5 exposure group presented lower vitamin D receptor and klotho expression and higher renin, angiotensin converting enzyme and cytochrome P450 27B1 expression in their kidneys than the control group. Intrarenal VEGF increased while VEGF receptor 2, angiopoietin-1, and Tie-2 protein expression decreased in the offspring rats exposed to maternal PM2.5. JG12-positive glomerular and peritubular capillary staining was reduced in the PM2.5 exposure group. Maternal vitamin D administration with PM2.5 restored intrarenal VEGF receptor 2 and angiopoietin-1 expression, together with the increase of JG12 expression in the capillary endothelium of adult offspring kidneys. Angiotensin converting enzyme activity was reduced by maternal vitamin D intake with PM2.5 exposure. Conclusions: Maternal PM2.5 exposure during nephrogenesis may lead to the impairment of renal vascular homeostasis in their adult offspring, and maternal vitamin D supplementation could attenuate PM2.5-induced renal vascular damage in the long-term.
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