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논문분류	춘계학술대회 초록집
제목	Pre- and Postnatal Chronic Exposure to Airborne Particulate Matter: Focus on Renal Fibrogenesis and the Role of Vitamin D Supplementation
저자	Hyung Eun Yim
출판정보	2024; 2024(1):
키워드
초록	Objectives: Long-term exposure to fine particulate matter (PM2.5) is the important risk factor for global premature mortality. This study aimed to investigate whether pre- and postnatal chronic PM2.5 exposure can induce renal fibrosis later in life. We also measured the effects of vitamin D supplementation on the underlying molecular pathways involved in renal damage induced by long-term PM2.5 exposure. Methods: Pregnant Sprague–Dawley rats were randomly assigned to three groups (N=3/group); normal saline (NS, controls), PM2.5, and PM2.5 with vitamin D during gestation and lactation. Their respective male rat offspring were subsequently exposed to NS, PM2.5, or PM2.5 with vitamin D during 3 to 8 weeks after birth (n=5/group). Their kidneys were taken for morphometric, immunohistochemical, and Western blot studies on postnatal day 56. Results: The adult offspring rats exposed to PM2.5 exhibited lower body weight and higher glomerular and tubular injury scores, compared to control rats; while these alterations were abolished by vitamin D intake. Persistent PM2.5 exposure elevated the expression of intrarenal renin and transforming growth factor-ß1, compared to control rats. Activation of mesenchymal cell marker proteins such as α-smooth muscle actin and vimentin was detected in the PM2.5-exposed kidneys although the expression of E-cadherin, a representative epithelial marker, was not repressed by PM2.5 exposure. Long-term vitamin D supplementation reversed the upregulation of renin, transforming growth factor-ß1, and α-smooth muscle actin in adult rat offspring kidneys. The expression of Wnt-4 and ß-catenin was not changed by the exposure to PM2.5 with or without vitamin D. Conclusions: Pre-and postnatal long-term exposure to airborne PM2.5 can activate intrarenal renin and fibrogenic molecules later in life. Long-term vitamin D supplementation may possibly reverse PM2.5-induced fibrogenic renal changes in adulthood.
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