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논문분류	춘계학술대회 초록집
제목	Correlation between Urine TGF- Levels and Decreased in Kidney Function in Type-2 Diabetes Mellitus Patients: A Non-Invasive Marker Candidate.
저자	Elfiani Elfiani
출판정보	2024; 2024(1):
키워드
초록	Objectives: The aim of this study is to observe the correlation between TGF-ß levels in urine and the decline in kidney function in Type-2 Diabetes Mellitus (DM) patients with DN. Methods: This study is a cross-sectional study involving 60 Type-2 DM patients who have been diagnosed for at least 5 years and are aged between 30 and 60 years old. The diagnosis of DN is based on an albumin-to-creatinine ratio ≥ 30 mg/g from a random urine sample quantified using the ELISA method. Subsequently, the correlation between urine TGF-ß and markers of kidney dysfunction is analyzed using the Spearman rank test. Results: The correlation analysis between urine TGF-ß and two kidney dysfunction markers showed significant correlations with the albumin-to-creatinine ratio (r=0.539; p< 0.01) and GFR (r=-0.590; p<0.01). Conclusions: Statistical analysis reveals a positive correlation between urine TGF-ß and the degree of proteinuria (albumin-to-creatinine ratio) and a negative correlation between urine TGF-ß and GFR. Urine TGF-ß levels correlate with the degree of kidney dysfunction in Type-2 DM patients.
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