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논문분류	춘계학술대회 초록집
제목	Metabolomic profiles in urine and blood revealed differences in metabolic pathways among patients with varying degrees of kidney dysfunction
저자	Hongquan Peng
출판정보	2024; 2024(1):
키워드
초록	Objectives: Biomarkers in urine and blood change with the progression of kidney disease. This study aimed to explore the metabolic pathways and their relative metabolites in the urine and blood of patients with different levels of kidney dysfunction. Methods: A total of 144 samples were collected and classified into four groups based on the patient’s measured glomerular filtration rate (mGFR). An untargeted metabolomics study of 144 urine and blood samples was performed using ultrahigh-performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS). Results: Blood metabolism analysis clearly discriminated patients with varying degrees of kidney dysfunction from urine metabolism analysis. In the urine, the metabolic pathways of steroid hormone biosynthesis, vitamin B6 metabolism, and glutathione metabolism were revealed to be related to different levels of kidney dysfunction. In blood, the associated metabolic pathways were involved in steroid hormone biosynthesis, vitamin B6 metabolism and glutathione metabolism. Conclusions: This study provides a comprehensive profile of the metabolic changes in the urine and blood of patients with varying degrees of renal dysfunction through untargeted metabolomics analysis. The novel biomarkers found in urine benefit the prediction of renal function through non-invasive sampling.
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