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논문분류	춘계학술대회 초록집
제목	Mediterranean lifestyle is associated with a lower risk of chronic kidney disease: population-based prospective study
저자	Hyo Jeong Kim
출판정보	2024; 2024(1):
키워드
초록	Objectives: There is evidence supporting the benefits of Mediterranean lifestyle in preventing chronic non-communicable diseases. However, the association between Mediterranean lifestyle and the development of chronic kidney disease (CKD) remains unclear. Methods: In this population-based prospective observational cohort study from the UK biobank cohort between 2006 and 2010, we included 157,715 participants who completed dietary assessment at least twice and had no CKD. The main predictor was the Mediterranean Lifestyle (MEDLIFE) index, which was assessed based on three blocks: 1) Mediterranean food consumption, 2) Mediterranean dietary habits, and 3) physical activity, rest, social habits, and conviviality. The primary outcome was incident CKD, defined by International Classification of Disease 10 codes or Operating Procedure Codes Supplement 4 codes. The secondary outcome was all-cause mortality. Results: At baseline, individuals with higher MEDLIFE index score had lower blood pressure, body mass index, and were less likely to have diabetes, hypertension, and cardiovascular disease. During a median follow-up of 11.2 years, primary outcome events occurred in 5,681 (3.6%) participants. In Cox regression models, the adjusted hazard ratio (aHR) per 1- increase in MEDLIFE index for incident CKD was 0.97 (95% confidence interval [CI], 0.96-0.98). Compared with quartile 1 of MEDLIFE index, the aHRs (95% CIs) for the quartiles 2 to 4 were 0.86 (0.90-1.03), 0.91 (0.85-0.98), and 0.78 (0.71-0.85), respectively. In secondary analysis, the risk of mortality decreased as MEDLIFE index increased, with the aHRs (95% CIs) for the quartiles 2 to 4 being 0.98 (0.92-1.04), 0.93 (0.87-0.99), and 0.88 (0.82-0.94), respectively. Conclusions: Higher MEDLIFE index was associated with a lower risk of incident CKD and all-cause mortality.
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