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논문분류	춘계학술대회 초록집
제목	Alterations in Innate Lymphoid Cells-related Cytokines with Chronic Kidney Disease progression
저자	Sehyun Jung
출판정보	2024; 2024(1):
키워드
초록	Objectives: The current researches on the ILC series are mostly focused on ILC2, particularly in animal models, exploring acute kidney diseases and chronic kidney disease (CKD). A more comprehensive study is needed to understand the contribution of innate lymphoid cells (ILCs) to the development and protection of CKD. ILC subgroups include ILC1, ILC2, ILC3, and regulatory ILC (ILCreg). ILC1 produces interferon (IFN)-γ in response to IL-12. IL-33 stimulates ILC2 to generate type 2 cytokines, including IL-4, IL-5, IL-6, and IL-13. IL-1β and IL-23 act as inducers of ILC3, and ILC3-derived IL-22, IL-17, and IL-2 are involved in immunologic homeostasis. Transforming growth factor (TGF)-β1 is induced by ILCreg. In this study, we investigated changes in ILCs-related cytokines according to CKD progression. Methods: In this prospective study, outpatients with CKD over 18 years of age who visited the Department of Nephrology at Gyeongsang National University Hospital from June to December 2021 were enrolled. Patients with CKD stage 1 and 5 were excluded. We analyzed blood samples from a total of 355 patients who provided informed consent. The estimated glomerular filtration rate (eGFR) was calculated using the 2012 CKD-EPI creatinine equation. Results: IL-13 levels increased with the progression of CKD (p=0.05), while TGF-β1 (p<0.001), and IFN-γ (p=0.013) levels decreased according to eGFR decreasing. There were positive correlations between eGFR and IFN-γ (R=0.16, p=0.039), and TGF-β1(R=0.31, p=0.00014), and a negative correlation between eGFR and IL-13 (R=-0.21, p=0.0087). Conclusions: We identified the changes in cytokines associated with ILC1, ILC2, and ILCreg in CKD patients. Significant changes in IL-13, IFN-γ, and TGF-β1 were observed according to CKD progression. Further studies are needed to elucidate the role and mechanisms of ILCs-related cytokines in CKD.
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