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논문분류	춘계학술대회 초록집
제목	The Impact of the Visceral-to-Subcutaneous Adipose Tissue Ratio on Renal Function Assessment after Nephrectomy in Kidney Donors
저자	Hyeran Park
출판정보	2024; 2024(1):
키워드
초록	Objectives: The Visceral-to-Subcutaneous Adipose Tissue Ratio (VAT/SAT ratio) serves as a metric for fat distribution, with higher values being associated with worse kidney function. In this study, we aimed to investigate whether the baseline CT-derived metric (VAT/SAT) can predict renal function in kidney donors after nephrectomy. Methods: A retrospective study was conducted on 628 kidney donors from Seoul St. Mary's Hospital between 2019 and 2022. We observed renal function changes within the first year post-nephrectomy. The VAT/SAT ratio was measured using baseline CT scans, and the impact of adipose tissue on changes in kidney function was evaluated through multivariate regression analysis. Results: Within the first month post-nephrectomy, the estimated glomerular filtration rate (eGFR) reached its lowest point, showing an average decrease of 33% (Figure 1). The cohort was divided into two groups: Group A (n=327) experienced a renal function decline of 33% or more within the first 30 days after kidney donation, while Group B (n=301) had a decline of less than 33% during the same period. Notably, this significant decline in eGFR persisted in both groups throughout the first year following nephrectomy (p=0.029). VAT/SAT ratio was divided into tertiles. In univariate and multivariate analyses, the increase in VAT/SAT ratio was identified as a factor influencing the deterioration of renal function post-nephrectomy. (Tertile 2; OR 1.595, 95% Confidence interval (CI): 1.060-2.401, Tertile 3; OR 2.164, 95% CI: 1.419-3.300) (Table 1.) Conclusions: After nephrectomy, renal function experiences the most significant decline within the first month, and this decline persists throughout the first year. A higher VAT/SAT ratio is associated with a more pronounced deterioration in renal function, suggesting the potential role of the VAT/SAT ratio in predicting renal function decline following nephrectomy.
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