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논문분류	춘계학술대회 초록집
제목	Causal effect of gut microbiota and diabetic nephropathy: a Mendelian randomization study
저자	Ganyuan He
출판정보	2024; 2024(1):
키워드
초록	Objectives: The interaction of gut microbiota (GM) with diabetes nephropathy (DN) drew our attention and a better understanding of GM on DN provided potential therapeutic approaches. However, the causal effect of GM on DN remains unknown. Methods: We applied two-sample Mendelian Randomization (MR) analysis to screen the significant bacterial taxa based on the GWAS data. Sensitivity analysis was conducted to assess the robustness of MR results. To identify the most critical factor on DN, Mendelian randomization-Bayesian model averaging (MR-BMA) method was utilized. Whether the reverse causality existed was verified by reverse MR analysis. Finally, transcriptome MR analysis was performed to investigate the mechanism of GM on DN. Results: We found eight taxa significantly related to DN. Among these taxa, genus Ruminococcus gauvreauii played a crucial role in DN. No causal relationship was identified between DN and GM in the reverse MR analysis. Furthermore, mapped genes FCGR2B and VNN2 might be the therapeutic targets for GM on DN. Conclusions: This work provided new evidence for the causal effect of GM on DN and potential biomarkers for DN. The significant bacterial taxa in our study provided new insights for the ‘gut-kidney’ axis, as well as unconventional prevention and treatment strategies for DN.
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