대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	CD25+ Tregs are associated with cardiac remodeling and prognosis in older patients with chronic kidney disease
저자	Ganyuan He
출판정보	2024; 2024(1):
키워드
초록	Objectives: Regulatory T cells (Tregs) are found to be associated with adverse cardiac remodeling. CD69+ T cells exerts immunoregulation function. In this study, we investigated the correlation of CD25+ Tregs and CD69+ T cells with cardiac remodeling and prognosis in older chronic kidney disease (CKD) patients. Methods: A retrospective study is comprised of 288 patients (88 non-CKD patients and 200 CKD patients). CD25+ Tregs and CD69+ T cells were identified by flow cytometry. Correlation of T cells subsets with clinical data and prognosis in older CKD patients were analyzed. Results: A total of 288 patients (mean age 82.10 ± 5.88) were recruited. CD4+CD25+ cells were found to be negatively correlated with pro-brain natriuretic peptide (pro-BNP) (P<0.05), interventricular septum (IVS) (P<0.05), left ventricle posterior wall (LVPW) (P<0.01) and relative wall thickness (RWT) (P<0.05). Similarly, pro-BNP (P<0.05), IVS (P<0.05) and LVPW (P<0.05) were negatively correlated with CD4+CD69+ cells and CD8+CD69+ cells were negatively correlated with LVPW (P<0.05), left ventricle end-diastolic dimension (LVDD) (P<0.05) and left ventricular mass (LVM) (P<0.01). Older CKD patients with higher levels of CD4+CD25+ cells manifested lower values of hypertrophy-related index. Kaplan-Meier survival showed patients with higher levels of CD4+CD25+ or CD4+CD69+ cells exhibited better survival in CKD groups (P<0.05). Conclusions: Our results demonstrated CD25+ Tregs were negatively correlated with left ventricular hypertrophy-related echocardiographic parameters in older CKD patients and better survival was observed in CKD patients with higher levels of CD4+CD25+ cells, which indicated CD25+ Tregs might improve cardiac remodeling and prognosis in older CKD patients.
원문(PDF)	PDF 원문보기

목록

위로가기