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논문분류	춘계학술대회 초록집
제목	Effect of Telitacicept In Elderly Patients With Active Systemic Lupus Erythematosus
저자	Niu Dan
출판정보	2024; 2024(1):
키워드
초록	Objectives: In the treatments of Systemic lupus erythematosus (SLE)， glucocorticoids and immunosuppression are associated with significant toxicities, especially in the long term or for the elderly.Telitacicept is a fusion protein that combines transmembrane activator and CAML interactor (TACI）with the Fc fragment of human IgG1 to target B lymphocyte stimulator (BLyS） and a proliferation-inducing ligand (APRIL）, thereby preventing their interaction with all of their B cell ligands,but seldomly used alone or with low prednison in elderly patients of SLE.In this study,two patients from China with active,autoantibody-positive SLE,receiving Telitacicept for six months，were abserved to evaluate the efficacy and safety of Telitacicept. Methods: Two patients were met the 2019 EULAR/ACR criteria for SLE and treated with telitacicept and sufficient symptomatic supports for 24 weeks without another immunosuppression.First patient ,femal,aged 79 years old and with SLEDAI score of 8,receive subcutaneous telitacicept at 160mg once weekly only.The second patient,femal,aged 85 years old and with SLEDAI score of 10，the level of serum creatinine was 239 umol/L,receive subcutaneous telitacicept at 80mg once two weeks in addition to prednison 10mg/d.Clinical signs were recorded before and after treatment, once 4 weeks. Results: The two patients were foud the Urinary total protein creatinine ratio(UPCR) and SLEDAI score decreased 50%,respectively at week 12 and 4.Then in two patients UPCR decreased continuously and serum creatinine(Scr) remained stable in the following time.The first patient was suffer from cystitis at week 20,then recovered after the withdrawal of telitacicept a week without UPCR and Scr increasing.Elevated blood sugar was found at week 16 in second patient,maybe bacause of prednison or improvement in diet, her blood sugar was effectively controlle dafter increasing the dosage of hypoglycemic drugs. Conclusions: The lower UPCR and SLEDAI were found after treatment with telitacicept in these two elderly patients of SLE,and no sevious side effects occured.
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