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논문분류	춘계학술대회 초록집
제목	Clinical Observation of Telitacicept Treatment for Systemic Lupus Erythematosus Nephritis Combined with Liver Damage
저자	Wang Xuehui
출판정보	2024; 2024(1):
키워드
초록	Objective: To investigate the efficacy and safety of telitacicept in the treatment of systemic lupus erythematosus nephritis (SLEN) combined with liver damage. Methods: One case of SLEN combined with liver damage was treated with intravenous telitacicept at a dose of 160mg once a week for 12 weeks, concomitantly with glucocorticoids and mycophenolate mofetil. The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) was used for clinical evaluation, and simultaneously monitoring 24-hour urinary protein quantification, changes of serological indicators, and the occurrence of adverse reactions. Results: After treatment with telitacicept combined with glucocorticoids and mycophenolate mofetil, the patient's proteinuria decreased, and edema was relieved. Compared with before treatment, complement levels and SLEDAI scores significantly improved, and the dose of glucocorticoids was significantly reduced. Meanwhile, there was partial relief of liver damage. Conclusion: Telitacicept is an effective method for treating SLEN, relieving clinical symptoms, reducing proteinuria, lowering lupus activity, and decreasing glucocorticoid dosage. It demonstrates advantages and better safety in terms of toxicity, side effects, and efficacy.
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