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논문분류	춘계학술대회 초록집
제목	Caveolin-1 Protects Against Acute Kidney Injury via Regulating Endoplasmic Reticulum Stress induced Ferroptosis
저자	Zhangzhe Peng
출판정보	2024; 2024(1):
키워드
초록	Objectives: This study aims to determine the effect and mechanism of caveolin-1 (Cav-1) in acute kidney injury (AKI). Methods: Immunofluorescence staining for Cav-1 and lotus tetragonolobus lectin (LTL) in kidney sections from normal subjects and AKI patients. And we induced AKI model by bilateral ischemia-reperfusion injury (IRI) of renal arteries or lipopolysaccharide (LPS) in wide type and Cav-1 knockout mice. Renal function and tubular injury were evaluated by serum creatinine, blood urea nitrogen, histological indexes of tubular injury, and expression of NGAL. Endoplasmic reticulum stress was evaluated by transmission electron microscope, the expression of GRP78, CHOP, p-IRE1, XBP1, ATF4, ATF6, eIF2αand p-PERK. GPX4 and Scl7A11 were measured to determine ferroptosis. Results: A significant increase of the expression of Cav-1 in renal tissue was observed in both IRI and LPS induced AKI models. Similar observation was also obtained in the patients with AKI. Cav-1 deficiency worsened renal function and caused more tubular injury in AKI. Additionally, knockout of Cav-1 aggravated endoplasmic reticulum stress and ferroptosis in AKI models. Conclusions: Our results revealed that Cav-1 may play a protective role in AKI by regulating ER stress induced ferroptosis, thereby identifying a novel and important therapeutic target for AKI.
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