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논문분류	춘계학술대회 초록집
제목	Cardiovascular outcomes of kidney transplantation in elderly patients: A nationwide cohort study from South Korea
저자	Sang Hun Eum
출판정보	2024; 2024(1):
키워드
초록	Objectives: Cardiovascular outcomes of kidney transplantation (KT) in elderly individuals have not been established. This study investigated the incidence and predictors of cardiovascular event (CVE) after KT. Methods: Data were obtained from the Korea Organ Transplantation Registry, a nationwide cohort study of KT recipients (KTRs). A total of 619 elderly KTRs (age ≥ 65 years) who underwent KT between May 2014 and June 2021 were included. The cumulative incidence and risk factors for CVE were evaluated using the Kaplan-Meier method and Cox proportional hazard model. Results: A total of 51 CVE cases were identified for 1513.39 person-years (median, 2.00 years). The cumulative 5-year incidence of CVE was 12.50%. KTRs who developed CVE had lower patient survival rate than those without CVE (P < 0.001), while graft survival did not differ. At baseline, a history of cardiovascular disease was a significant predictor for CVE (hazard ratio [HR], 3.407; 95% confidence interval [CI], 1.154–10.061; P = 0.027), while age did not affect the development of CVE. At post-KT 6 months, higher levels of glucose (HR, 1.013; 95% CI, 1.004–1.022; P = 0.004) and triglycerides (HR, 1.010; 95% CI, 1.002–1.017; P = 0.012), and lower hemoglobin (HR, 0.630; 95% CI, 0.430–0.924; P = 0.018) were associated with a higher risk of CVE. A subgroup analysis showed a significant increase in CVE incidence in KTRs who developed posttransplant diabetes mellitus (PTDM) by log-rank test (p = 0.022), and time-varying Cox regression analysis showed PTDM was significantly associated with CVE (HR, 3.45; 95% CI, 1.101 – 10.805; P = 0.034). Conclusions: In elderly KTRs, CVE was associated with lower patient survival. A history of cardiovascular disease, and post-KT factors including high glucose and triglycerides levels and low hemoglobin may be responsible for CVE.
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