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논문분류	춘계학술대회 초록집
제목	Association and prognosis between alcoholic liver disease and hyponatremia
저자	Hyungsuk Lee
출판정보	2024; 2024(1):
키워드
초록	Objectives: Hyponatremia is an electrolyte disorder commonly observed in hospitalized patients. Liver cirrhosis is one of the common causes of hyponatremia, but studies on the direct relationship between alcohol and hyponatremia are rare. Therefore, we would like to investigate the relationship and prognosis between alcohol and serum sodium in patients hospitalized at a hepatology department. Methods: Patients admitted to the gastroenterology department(hepatology) at Gyeongsang National University Hospital from March 2016 to November 2023 were eligible. The inclusion criteria included adults aged 18 years or older and patients hospitalized with hepatitis or alcoholic liver disease. The exclusion criteria were those with liver cirrhosis, a major risk factor in hyponatremia. The study was conducted by dividing into alcohol group(included alcoholic liver disease, alcoholic hepatitis), and non-alcohol group(included hepatitis, toxic hepatitis). Results: Of the total 1,198 patients, 208 (17.4%) had alcoholic liver disease, and hyponatremia (Na<136mEq/L) was statistically significantly more common in the alcohol group (48.1% vs. 29.9%, p < 0.001). Statistical significance was shown in the alcohol group even when divided into moderate (Na <125 mEq/L) (10.1% vs. 2.1%, p < 0.001) and severe (Na <115 mEq/L) hyponatremia (1.9% vs. 0.2%, p = 0.001). There was no difference in mortality rate (12.5% vs. 10.1%, p = 0.305) between the two groups, but the number of readmissions (0.57 ± 1.51 vs. 0.32 ± 0.91, p = 0.024) and readmission rate (24.5% vs. 17.1%, p=0.012) was significantly higher in the alcohol group. The hospitalization period was also significantly longer in the alcohol group (8.8±10.9 vs. 7.2±5.1 p = 0.032), and hepatic failure was significantly more frequent in the alcohol group (15.9% vs. 4.0% p <0.001). Conclusions: Alcoholic liver disease is an important causative factor for hyponatremia and requires appropriate treatment and treatment as it increases medical costs, increases social costs, and affects patient prognosis.
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