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논문분류	춘계학술대회 초록집
제목	A Rare Case of a 74 year-old Filipina with Sjogren's Syndrome presenting with Tubulointerstitial Nephritis on Kidney Biopsy
저자	Wilmark Gular
출판정보	2024; 2024(1):
키워드
초록	Background: Sjogren's Syndrome is a chronic, systemic, autoimmune disorder caused by lymphocytic infiltration of exocrine glands, mostly the lacrimal and salivary glands. It commonly presents with dry eyes and dry mouth and is seen primarily among women with onset at 40 to 50 years of age. Renal involvement in Sjogren's syndrome is rare and is present in about 5% of patients. The abnormalities can include tubular dysfunction, mainly tubulointerstitial nephritis, distal renal tubular acidosis, nephrogenic diabetes insipidus, and nephrolithiasis. Case Report: We present a case of a 74-year-old hypertensive Filipina who came in due to elevated Creatinine and non-nephrotic range proteinuria with hypokalemia as part of Distal Renal Tubular Acidosis. Patient had an ANA titer of 1:160 and she underwent renal biopsy to rule out Lupus Nephritis. Histopathologic findings showed acute and chronic tubulointerstitial nephritis, mild glomerular abnormality, negative staining on immunofluorescence with no electron dense deposits. She tested positive for AntiSSA and was treated as a case of Sjogren's Syndrome. Conclusions: The prevalence of Sjogren's Syndrome among Filipinos has not been established. At present, data is limited on few case reports of Sjogren's Syndrome in the Philippines. This was a rare case of Sjogren's Syndrome in a Filipina presenting with acute kidney injury, proteinuria, and renal tubular acidosis with tubulointerstitial nephritis on kidney biopsy. Patient was eventually referred to Rheumatology service and was started on oral immunosuppressant.Sjogren's Syndrome should be considered as a differential among patients presenting with elevated Creatinine, proteinuria, hypokalemia, and renal tubular acidosis.
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