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논문분류	춘계학술대회 초록집
제목	Differential Composition of CT-derived Visceral and Subcutaneous Fat in Sarcopenic Chronic Kidney Disease Patients
저자	Seok-hyung Kim
출판정보	2024; 2024(1):
키워드
초록	Objectives: Sarcopenia and body fat composition are important factors to consider in both general population and chronic kidney disease (CKD) patients. In this study, we aimed to investigate the relationship between muscle mass and fat mass, including subcutaneous and visceral fat, in CKD patients. We conducted a comprehensive analysis of body composition using bioelectrical impedance analysis (BIA) and computed tomography (CT) imaging in a CKD cohort and compared the results with those observed in the general population. Methods: To quantify muscle mass, we calculated the appendicular skeletal muscle (ASM) by the summing skeletal muscle mass (SMM) of both the lower limbs and arms. The SMM measurements were obtained through BIA. We utilized synapse volumetry to measure the subcutaneous and visceral fat volume in CT cross-sectional images. Results: Among the 189 participants included in the analysis, the mean age was 58.6 ± 17.7 years. The mean eGFR was 47.6 ± 35.6 mL/min/1.73 m2. Notably, CKD patients were found to be significantly older than those without CKD. Additionally, CKD patients exhibited a lower mean BMI compared to those without CKD. It's worth noting that participants with CKD had lower subcutaneous fat and higher visceral fat compared to those without CKD. Within the non-CKD group, participants with higher muscle mass exhibited statistically significant increases in both BMI and waist circumference compared to those with lower muscle. Additionally, both subcutaneous and visceral fat showed statistically significant elevations in the higher muscle mass group. However, in the CKD group, it was observed that subcutaneous fat was lower in sarcopenic patients, but there was no statistically significant difference in visceral muscle mass between the higher muscle mass group and sarcopenic patients, even after adjusting for relevant variables. Conclusions: In the CKD group, sarcopenic patients, lower skeletal muscle mass and relatively higher visceral mass were observed compared to the non-CKD group.
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