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논문분류	춘계학술대회 초록집
제목	Comparison of Long Term Outcomes among the Treated and Untreated Hepatitis C positive Kidney Transplant Recipients
저자	Sana Shadab
출판정보	2024; 2024(1):
키워드
초록	Objectives: To study the long term impact of hepatitis C treatment on the patient and graft outcome in Kidney Transplant Recipients(KTR) Methods: Type of Study - Ambispective cohort study, conducted at A.I.I.M.S,Delhi, from August 2019 to February 2021. Inclusion Criteria - All KTR aged > 18 years, HCV positive before transplant, with at least 1 year follow up post-transplant Exclusion Criteria - coinfected with Hepatitis B or HIV. Treated group - HCV infected KTR who attained SVR with anti-viral therapy, while Control group included those who could not be treated or non responders to therapy Results: Among 2883 renal transplants done from 1994 to 2019 at our centre, 332 patients were included in the study.114 (34.3%) patients formed the treated group, 86 (75.4%) received DAA, all attained SVR, but only 28 patients (75.6%) treated with IFN had SVR. 218 (65.7%) patients formed the control group. The mean age among the two groups were comparable, 33.0 ± 9.3 years (treated) vs 32.3 ± 9.0 years( untreated). The median follow up was 48 (15-89.5) months in the control group and 40 (25-59) months in the treated group. There was significantly increased mortality among the control group 57 (26.1%) vs the treated group 7 (6.1%), (p <0.001). There were more serious infections seen in the control group; 110 (50.4%) as against the treated group 51 (44.7%), however it was insignificant. HCV treated patients had better graft survival (93%), against 76.2% in control group (p <0.001). The control group had significantly more incidence of liver cirrhosis 19 (8.7%) vs treated group 1 (0.8%) (p-0.004). Out of these 19 patients, 17 (7.7%) developed decompensated liver disease till the last follow up. Conclusions: HCV positive renal transplant recipients who were treated, had significant benefit in terms of patient and graft survival as compared to untreated and non-responsive patients
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