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논문분류	춘계학술대회 초록집
제목	Dietary Inflammatory Index and Chronic Kidney Disease Risk: Exploring the Mediation Effects of Circulating Proteins
저자	Hee Byung Koh
출판정보	2025; 2025(1):
키워드	Dietary Inflammatory Index, Chronic kidney disease, Diet, Inflammation
초록	The link between diet-induced inflammation and cardiovascular disease or cancer risk has been previously observed. However, its role in chronic kidney disease (CKD) development and underlying mechanisms remains unclear. This study investigates the association between the Dietary Inflammatory Index (DII) and CKD risk, exploring potential mechanisms through proteomics-based mediation analysis. This study included 159,063 UK Biobank participants without underlying CKD (median age: 57.0 years; 53.0% female). The Dietary Inflammatory Index (DII) was assessed via a 24-hour dietary recall and categorized into quartiles. Incident chronic kidney disease (CKD) was identified using ICD-10 and OPCS-4 codes. In a sub-cohort with creatinine follow-up, CKD was also defined as an eGFR <60 mL/min/1.73 m². Proteomics-based mediation and protein–protein interaction analyses explored potential mechanisms linking diet-induced inflammation to kidney function. During a median of 11.2 years of follow-up, CKD occurred in 4,395 patients. CKD incidence was progressively higher in participants with higher DII. Cox regression analysis revealed that the adjusted hazard ratios (aHRs) for incident CKD increased in a stepwise manner towards higher DII quartiles (aHR [95% CI]; Q2, 1.08 [0.99-1.18]; Q3, 1.14 [1.04-1.25]; Q4, 1.17 [1.06-1.29]) relative to Q1 (P for trend <0.001). Similar results were observed with eGFR-defined CKD (aHR [95% CI]; Q2, 1.16 [0.99-1.36]; Q3, 1.20 [1.02-1.41]; Q4, 1.27 [1.07-1.52] relative to Q1; P for trend <0.001). Mediation and protein-protein interaction analysis revealed that circulatory proteins linked to death receptor activity, tumor necrosis factor receptor-related pathways, and immune regulation mediate the association between diet-induced inflammation and CKD development. A higher DII was associated with an increased incident CKD risk in adults with normal kidney function. This association may be due to changes in the circulating protein profile induced by a diet with high inflammatory potential.
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