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논문분류	춘계학술대회 초록집
제목	Role of P-Cresyl Sulfate in Neointimal Hyperplasia and Vascular Dysfunction: Evidence from a Murine Model
저자	Shina Lee
출판정보	2025; 2025(1):
키워드	uremic toxin, vascular access, neointimal hyperplasia
초록	Vascular access failure is a leading cause of hospitalization and morbidity in patients undergoing hemodialysis, primarily due to neointimal hyperplasia resulting from vascular smooth muscle cell (SMC) proliferation. Our preliminary research demonstrated that p-Cresyl sulfate (p-CS) directly induces SMC proliferation and promotes oxidative stress and endothelial dysfunction, leading to neointimal hyperplasia. This study aimed to further investigate whether p-CS promotes SMC proliferation and endothelial dysfunction in a mouse model. C57 mice underwent either a 1/2 nephrectomy (1/2 NR) or a sham operation at 8 weeks of age, followed by p-CS injections for 4 weeks. The extent of neointimal hyperplasia was assessed at 20 weeks in 7 groups: sham (n = 7), 1/2 NR + p-CS (n = 10), 1/2 NR + p-CS + N-acetylcysteine (NAC) (n = 8), 1/2 NR + p-CS + probenecid (n = 8), and 1/2 NR + probenecid (n = 8). The neointimal hyperplasia area of the thoracoabdominal aorta was significantly larger in the 1/2 NR + p-CS group compared to the sham group, while NAC and probenecid treatment effectively prevented this increase. Our findings confirm that p-CS directly induces neointimal hyperplasia in a mouse model. Further studies are warranted to explore the clinical implications of p-CS in vascular access dysfunction.
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