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논문분류	춘계학술대회 초록집
제목	Efficacy of Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Dialysis Patients: A Single-Center Experience
저자	Olimkhon Sharapov
출판정보	2025; 2025(1):
키워드	CKD, DIALYSIS, MBD, HYPERPARATHYROIDISM, CINACALCET
초록	We decided to study the effectiveness of cinacalcet in dialysis patients in the Uzbek population. We randomly selected 50 patients on dialysis. We divided the patients into two groups: group A consisted of 30 patients who were prescribed cinacalcet at a dose of 30 mg/day in addition to the treatment, and group B consisted of 20 patients who served as a control group. The patients were examined for 3 months; the control points were the 30th and 90th days. The calcium level in group A before treatment was 2.48±0.47 mmol/l and significantly decreased after treatment, amounting to 2.17±0.38 mmol/l (p<0.05). In group B, it was 2.51±0.56 mmol/l and 2.49±0.97 mmol/l (p>0.05), respectively. Blood phosphorus in group A, after 90 days, decreased from 2.83±0.86 mmol/l to 1.72±0.76 mmol/l, and in group B from 2.81±0.91 mmol/l to 2.73±0.65 mmol/l. Before the study, the PTH level in group A was 1132.3±182.7 pg/ml, in group B – 1083.9±169.3 pg/ml. After 30 days of the study, in group PTH decreased by 18% and was 928.5±98.7 pg/ml (P<0.05), while in group B it changed insignificantly – 1053.7±158.6 pg/ml (P>0.05). On the 90th day of treatment, the PTH level in group A decreased by another 16%, amounting to 779.9±83.7 pg/ml (P<0.05), thereby decreasing by 31.1% (P<0.05) from the initial level. And in group B it remained at approximately the same level, amounting to 1032.1±143.8 pg/ml. Also, in group A, the symptoms of hyperparathyroidism symptoms such as pain in bones and joints, muscle weakness, fatigue, decreased tone decreased in patients and the well-being of patients improved, which was not observed in patients in group B. In patients who received cinacalcet at a dose of 30 mg/day in addition to their current treatment, PTH levels decreased by more than 30% compared to the control group without cinacalcet.
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