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논문분류	춘계학술대회 초록집
제목	Elevated Hepcidin Is an Independent Risk Factor for the Progression of Coronary Artery Calcification in Patients With Chronic Kidney Disease
저자	Ye Eun Ko
출판정보	2025; 2025(1):
키워드	chronic kidney disease, hepcidin, coronary artery calcification
초록	Although hepcidin is well known for its role in iron metabolism, recent studies also showed its relationship with cardiovascular events. A previous study demonstrated a positive correlation between hepcidin level and the incidence of atherosclerotic disease. Moreover, elevated hepcidin level was related to increased cardiovascular outcome in dialysis patients. However, the relationship between hepcidin and coronary artery calcification (CAC) in patients with CKD was not well studied. Present study was aimed to investigate the association between hepcidin and CAC progression in patients with non-dialysis chronic kidney disease. A total of 1,147 CKD (stage 1 to 5) patients were enrolled from the nationwide multicenter prospective observational cohort of KNOW-CKD (KoreaN Cohort Study for Outomes in Patients With Chronic Kidney Disease). Patients were divided into four groups based on coronary artery calcification (CAC) severity: None (CAC score = 0), Mild (< 100), Moderate (100-300), and Severe (> 300). Primary outcome was CAC progression, which was defined as an annualized percentage change in CAC score ≥ 0.15 (15%). An annualized percent change was calculated as follows: {(CAC score at the end - CAC score at the entry)/(CAC score at the entry +1) + 1}(12/follow-up months) -1. The mean age of study subjects was 52.8±12.0 years and 688 (59.7%) were male. Baseline hepcidin levels differed significantly among CAC severity groups (14.5±13.7, 17.1±14.9, 15.4±13.3, 13.5±12.0; P=0.04). After log transformation, multivariate analysis showed each 1-unit increase in log(hepcidin+1) associated with higher CAC progression risk (OR 1.95; 95% CI, 1.06-3.60; P=0.03). Subgroup analysis revealed no significant association in patients with baseline CAC=0 (P=0.29), but significant association in those with baseline CAC>0 (OR 3.15; 95% CI, 1.18-8.39; P=0.02). Hepcidin level may be an independent predictor of CAC progression in CKD patients.
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