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논문분류 춘계학술대회 초록집
제목 Factors Influencing Skeletal Muscle Density and Skeletal Muscle Index Derived from Abdominal CT Scans of Initial Hemodialysis Patients
저자 Suyeon Han
출판정보 2025; 2025(1):
키워드 Skeletal muscle density, hemodialysis, sarcopenia, Skeletal muscle index, Comupted Tomography
초록 Skeletal muscle index(SMI) and skeletal muscle density(SMD) derived from L3 abdomen CT scan provide insight into muscle mass and quality. This research explores the factors affecting SMD and SMI in initial hemodialysis patients. 458 patients who initiated hemodialysis in Daejeon Saint Mary Hospital with abdomen non-enhanced CT scan from Jan. 2018~ Dec. 2023 were enrolled in this retrospective study. Skeletal muscle density and skeletal muscle index were derived from abdomen non-enhanced CT scan using image J program. Pearson’s correlation analysis and multivariate linear regression was conducted to examine the correlation between baseline characteristics (age, sex, height, weight, laboratory data and comorbidities) with SMI and SMD. SMD had a significant positive correlation with male sex, height, albumin, and PNI. Conversely, SMD showed a significant negative correlation with age and BMI. Male sex (β=0.341, p<0.001), younger age (β=-0.364, p<0.001), low BMI (β=-0.297, p<0.001), high creatinine (β=0.135, p<0.001) and high albumin (β=0.242, p<0.001) were not only significant but also independently and critically associated with high SMD. SMI had significant positive correlation with male sex, BMI, height, weight, SMA, perimeter, creatinine and GNRI. Conversely, SMI showed a significant negative correlation with age, and corrected calcium. In multivariate linear regression showed that male (β=0.244, p<0.001), younger age (β=-0.122, p<0.001), higher BMI (β=0.486, p<0.001), and lower corrected calcium (β=-0.134, p<0.001) remained significant and independently associated with high SMI. Male sex and younger age were associated with both SMI and SMD. However, BMI had an inverse relationship with SMD, while higher BMI was linked to an increase in SMI. Additionally, albumin was only associated with SMD.
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