대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Safety and Vascular Effects of Low-Dose Ramipril in Living Kidney Donors: A Randomized Controlled Trial
저자	Ankur Chaudhary
출판정보	2025; 2025(1):
키워드	Living kidney donors, ACE inhibition, Endothelial dysfunction, Ramipril, Flow mediated dilatation
초록	Living kidney donors may be adversely affected due to lowering of GFR post nephrectomy. Besides their anti-hypertensive actions, ACE inhibitors (ACEi) have positive effects on vascular function. We evaluated the safety of low dose Ramipril (1.25mg) in kidney donors and impact on flow mediated dilatation (FMD) at 6 months post donation. In a single centre, open label, randomized control trial, all prospective living renal donors between 18-60 years, with no underlying hypertension or allergy to ACEi were enrolled. Baseline eGFR and FMD were recorded. Subjects were randomized (1:1 ratio) at discharge to receive either daily dose of 1.25 mg of Ramipril or no medication. Repeat FMD and eGFR were measured at 6 months. Subjects were withdrawn from study if serum creatinine increased by >25% as compared to baseline, or serum potassium rose to >5.5 mEq/L, or systolic blood pressure (SBP) fell to <90 mm Hg or by >25% as compared to baseline. 59 subjects post donor nephrectomy were enrolled and randomised: 29 to Intervention/Ramipril and 30 to Control arm. At 6 months, 19 participants followed up in intervention and 23 in control arm. One participant in intervention arm (3.44%) developed side effect in form of increase in serum creatinine >25% from baseline which led to discontinuation of drug. In the control arm, 2 (6.7%) participants had rise in serum creatinine. Mean difference in eGFR was 25.4±16.3ml/min/1.73m2 in intervention versus 26.0±17.1ml/min/1.73m2 in control arm (p=0.909). Mean difference in FMD at 6 months vs baseline was 3.63±10.76% in intervention while -2.62±10.28% (p=0.098) in control arm. Use of ramipril in dose of 1.25 mg once daily in living kidney donors was safe. A trend in improvement in vascular function was noted in intervention arm suggesting further study the effect of ACEi on vascular function in post kidney donation with adequate sample size.
원문(PDF)	PDF 원문보기

목록

위로가기