대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Optimizing Tacrolimus Dosage After Kidney Transplantation: A Comparison of Trough Levels and Concentration/Dose Ratios
저자	Woo-yeong Park
출판정보	2025; 2025(1):
키워드	Kidney transplantation, Tacrolimus, Graft rejection, Survival rate
초록	Tacrolimus (Tac) trough concentration (C₀) has been used to maintain optimal Tac levels to prevent the risk of graft rejection or toxicity due to its narrow therapeutic window. Recently, the Tac metabolism rate, defined as the blood concentration normalized by its daily dose (C₀/D ratio), has been reported as a useful measure, but its effectiveness remains controversial. We enrolled 60 patients who underwent kidney transplantation (KT) between 2013 and 2016. We retrospectively investigated C₀ and the C₀/D ratio at 1, 3, 6, and 12 months after KT. We analyzed the incidence of delayed graft function (DGF), de novo donor-specific antibody (DSA) formation, acute rejection, infection, graft function, and graft survival based on C₀ and the C₀/D ratio. The mean age of kidney transplant recipients (KTRs) was 45 ± 9.2 years, with 43.3% being male. At 3 months post-transplant, the median C₀ level was 7.15 ng/mL, and recipients were categorized into two groups: G1 (<7.15 ng/mL) and G2 (≥7.15 ng/mL). Graft function (eGFR) at 3, 6, and 12 months was significantly higher in G1 than in G2. However, the incidence of delayed graft function (DGF), de novo donor-specific antibodies (DSA), acute rejection, and infection showed no significant differences. Kaplan-Meier analysis indicated superior death-censored graft survival in G1. Similarly, the median C₀/D ratio at 3 months was 1.67, forming two groups: G3 (<1.67) and G4 (≥1.67). Graft function and de novo DSA incidence were significantly higher in G1 than in G2. However, no significant differences were observed in DGF, acute rejection, or infection rates between the groups. Kaplan-Meier analysis showed significantly better death-censored graft survival in G4 compared to G3. Tac C₀/D ratio may help optimize Tac dosage to prevent graft rejection or toxicity in KTRs.
원문(PDF)	PDF 원문보기

목록

위로가기