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논문분류	춘계학술대회 초록집
제목	Improvement in Chronic Kidney Disease Associated Pruritus Following Kidney Transplantation
저자	Manish Malik
출판정보	2025; 2025(1):
키워드	Chronic Kidney Disease, Pruritus, Kidney Transplantation, IL-31, 5D Itch Score
초록	Chronic Kidney Disease associated Pruritus (CKD-aP) or uremic pruritus (UP) is defined as itching directly related to the kidney disease. Interleukin-31 (IL-31), an itchy cytokine, has been proven to play a significant role in developing the itch in multiple dermatological disorders. We aimed to determine the change in the 5D itch score and serum IL-31 levels in pre and post-transplant period. In this prospective observational study, Itch assessment was done using a 5D ITCH scale of 202 patients with CKD stage V planned for renal transplantation. Out of them, 89 patients had pruritus, and 3 patients were excluded from the study as they suffered from a primary skin disorder. Finally, 86 (42.6%; Males-75.5%.) patients with pruritus. Dialysis vintage varied widely in our study with Pre-emptive renal transplant to a maximum dialysis duration of 60 months. A significant difference (p<0.001) was found between the mean IL-31 values across different itch categories. Pruritus completely improved in 55(63.9%) patients, while 25(29.1 %) patients reported mild itch, and 6(6.9%) patients still had moderate itch following 1 month of transplantation. Mean serum IL-31 levels decreased significantly from 145.02±103.27 to 89.91±59.51 after the transplantation. Similarly, a significant decrease was found in the mean itch scores from 15.03±4.36 to 7.44±2.11 following transplantation. In the post-transplant period, a moderate positive correlation was observed between overall itch scores and IL-31 levels (r = 0.411, p = 0.001). Change in itch scores was positively correlated with the change in serum IL-31 levels from the pre-transplant to the post-transplant period (r = 0.464, p = 0.001). Our results clearly demonstrate a significant correlation between itch score and serum IL-31 levels both in the pre and post-transplant period. The change in the itch score correlates with the change in the 5D itch score.
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