대한신장학회

논문분류	춘계학술대회 초록집
제목	From Biomarker to Modifiable Risk Factor? A Bibliometric Analysis of Hyperuricemia in Pediatric Chronic Kidney Disease
저자	Adinda Paramitha Sukma Damayanti
출판정보	2026; 2026(1):
키워드	hyperuricemia, pediatric, chronic kidney disease, modifiable risk factor
초록	Objectives: Chronic kidney disease in children carries substantial morbidity and risk of progression to end-stage kidney disease. Identifying modifiable factors influencing renal decline remains a priority in pediatric nephrology. Hyperuricemia has been linked to faster decline in glomerular filtration rate through mechanisms such as endothelial dysfunction and inflammation. However, whether hyperuricemia represents a biomarker of renal impairment or a modifiable contributor to disease progression remains debated. This study evaluated global research trends and thematic evolution of hyperuricemia in pediatric chronic kidney disease using bibliometric analysis. Methods: A bibliometric analysis was performed using the Dimension database to identify publications related to hyperuricemia and chronic kidney disease in pediatric populations from 2008 to 2026. The search strategy combined terms for uric acid, chronic kidney disease, and pediatric age groups, limited to the title and abstract fields. Bibliographic records were exported and analyzed using VOSviewer to evaluate annual publication trends, citation patterns, country contributions, collaborative networks, and keyword co-occurrence mapping. Results: A total of 261 publications were identified from 2008 to 2026, showing a gradual increase in annual output. The United States and China were the leading contributors, indicating strong international collaboration. Keyword co-occurrence analysis revealed four clusters: association between serum uric acid and renal decline, epidemiologic risk profiling, genetic mechanisms, and clinical treatment. Temporal analysis showed a shift from association-focused studies toward treatment-related themes, although interventional research remained limited. Conclusion: Research on hyperuricemia in pediatric chronic kidney disease has increased, with growing emphasis on treatment-related aspects. However, interventional evidence remains limited. The relatively small number of publications suggests that this topic is still an emerging and underexplored field. These findings highlight a shifting scientific perspective and underscore the need for further studies to clarify the role of hyperuricemia as a modifiable risk factor in disease progression.
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