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논문분류	춘계학술대회 초록집
제목	Early Changes in Mineral Metabolism and Bone Health After Kidney Transplantation: A One-Year Retrospective Analysis
저자	Seung Yun Chae
출판정보	2026; 2026(1):
키워드	Bone mineral density, Bone turnover markers, Chronic kidney disease-mineral and bone disorder, Kidney transplantation, Mineral metabolism
초록	Objectives: Chronic kidney disease mineral and bone disorder (CKD-MBD) increases fracture risk in kidney transplant recipients (KTRs). Understanding post-transplant changes in mineral metabolism and skeletal health is essential for management. Methods: This retrospective study included 20 patients who underwent kidney transplantation between August 2021 and April 2024. Bone mineral density (BMD) and trabecular bone score (TBS) were measured by dual-energy X-ray absorptiometry. Serum parameters included calcium, phosphorus, vitamin D, intact parathyroid hormone (PTH), C-terminal telopeptide of type I collagen (CTx), and procollagen type 1 N-terminal propeptide (P1NP). Parameters before and after transplantation were compared using paired t-test. Results: Mean age was 56.5 ± 9.9 years, and 55.0% were male. After 12 months, calcium increased (9.06 ± 1.14 to 10.03 ± 0.63 mg/dL), phosphorus decreased (6.02 ± 1.84 to 3.51 ± 0.55 mg/dL), and intact PTH declined by 65.3% (287.03 ± 218.09 to 99.44 ± 91.80 pg/mL, all p < 0.001). CTx decreased by 48.8% (p = 0.006) and P1NP by 67.8% (p = 0.029). Femoral neck BMD T-score decreased (−1.14 ± 1.09 to −1.51 ± 0.97, p = 0.010), while spine BMD and TBS showed no significant changes. Conclusion: Within the first year after transplant, KTRs showed biochemical normalization of mineral metabolism, reduced bone turnover, preserved trabecular bone quality and spine BMD, and mild femoral bone loss, consistent with early skeletal adaptation. Long-term monitoring is warranted.
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