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논문분류	춘계학술대회 초록집
제목	The Effects of Endothelial Microparticles Induced by Indoxyl Sulfate
저자	Jung-Hwa Ryu1, Sung-Pil Choi2, Dong-Ryeol Ryu1, Duk-Hee Kang1, Kyu-Bok Choi1, Seung-Jung Kim1
출판정보	2013; 2013(1):
키워드	혈관내피세포미세입자, 정맥 신생내막증식, TGF-β/ Endothelial microparticle, Venous neointimal hyperplasia, TGF-β
초록	Vascular access failure is one of the critical risk factor for the mortality or morbidity in hemodialysis(HD) patients. The venous neointimal hyperplasia (VNH) is the main pathogenesis of the access stenosis, and recently it was reported that the proliferation of vascular smooth muscle cells (VSMCs) promoted by activation of TGF-β signaling took a main portion for VNH. Endothelial microparticles (EMPs) are produced by various inflammatory stimulants associated with endothelial injury and increased in various vascular disease and uremic condition. However, it has not been established about the definite effects of EMPs on VSMCs. This study is aimed to isolate the EMPs induced by indoxyl sulfate (IS), well-known uremic toxin and to investigate whether the EMP directly stimulates the downstream of TGF-β signaling in VSMCs.
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