대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Organ Function Preservation by the Combination Treatment of the OptImuM dose of Calcineurin Inhitor and Mycophenolate Sodiium in Kidney Recipients: OPTIMUM Study
저자	Su Kil Park8, Jung Pyo Lee2, Yong-Lim Kim3, Joong-Kyung Kim4, Yeong Hoon Kim5, Wooseong Huh6, Chul Woo Yang7, Yon Su Kim1
출판정보	2013; 2013(1):
키워드	신장이식, 다기관연구, 이식신 기능/ Kidney transplantation, Multicenter studies, Graft function
초록	Background, Introduction: of the calcineurine inhibitors has significantly increased 1-year renal allograft survival, however, they have not extended long-term allograft survival. Here, we have hypothesized that low tacrolimus(Tac) dose together with mycophenolate sodium (MPS) dose adjustment will preserve better renal graft function without rising adverse effects in the recipients with stable graft function more than one year post-transplantation. Methods: A total of 288 Korean renal allograft recipients from 7 centers were randomized for treatment with either conventional dose Tac (5-10 pg/ml target trough level) and usual-dose MPS (360 mg twice a day) or low-dose Tac (2-5 pg/mL target trough level) and high-dose MPS (720 mg twice a day). 147 patients received a conventional dose and 141 received a low dose of Tac. Results: The time of enrollment from kidney transplantation was 2.5±1.2 years in both groups. After 12 months later, the trough levels were significantly different (6.5±1.8 vs. 4.4±1.7 ng/ml, p<0.001). eGFR at 12 months of low-dose Tac group was superior to that of conventional-dose Tac group, although it was not statistically significant (low-dose vs. conventional-dose 66.6±18.2 vs.63.1±16.6 mL/min/1.73m2, p=0.138). During the 12 months, rates of acute rejection, opportunistic infection and leukopenia were similar in both groups. Graft failure occurred in 1 patient of conventional-dose Tac group. However gastrointestinal adverse events requiring change of immunosupression occurred more in low-dose Tac group than in conventional-dose group (6.4% vs. 3.7%, p=0.033). Conclusion: Low-dose Tac exposure combined with intensified mycophenolate sodium could provide the better renal function in immunologically stable period after kidney transplantation.
원문(PDF)	PDF 원문보기

목록

위로가기