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제목	Impact of the Baseline Anti-A/B Antibody Titer on the Clinical Outcome in ABO Incompatible Kidney Transplantation
저자	Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
출판정보	2013; 2013(1):
키워드	혈액형 불일치, 항체역가, 신장이식/ ABO mismatch, Antibody titer, Kidney transplantation
초록	Background/AIMS: We investigated the impact of the baseline anti-A/B antibody titer on the clinical outcome in ABO-incompatible kidney transplantation (IKT). Methods: We included 183 patients who had undergone KT (40 ABO IKT and 143 ABO-compatible KT). Eight patients with a baseline titer of ≥1:512 were assigned to the high-titer group and thirty-two patients with a baseline titer of ≤1:256 were assigned to the low-titer group. Patients who underwent ABO-compatible KT were used as the control group. We compared the clinical outcomes of the three groups. Results: Before transplantation, the high-titer group displayed more frequent antibody rebound, as shown in a lower titer reduction rate, and more difficulty reaching the target titer (1:16) than the low-titer group. During post-operative period and out-clinic follow-up, antibody rebound was more frequent, and the rate of acute rejection and infection were significantly higher and allograft function was lower in the high-titer group than in the low-titer and control groups. Multivariate analysis showed that high baseline antibody titer was an independent risk factor for acute rejection. Conclusion: ABO IKT in high-titer group (baseline titer≥1:512) required greater caution compared to low titer group because of the higher tendency of antibody rebound and the risk for acute rejection.
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