대한신장학회

논문분류	춘계학술대회 초록집
제목	The Correlation and Comparison Among Three Methods for GFR Measurement
저자	Ran-hui Cha1, Yun Jung Oh2, Chung Sik Lee2, Na Ra Shin3, Jin Ho Hwang4, Hajeong Lee3, Dong Ki Kim3, Suhnggwon Kim3, Yon Su Kim3
출판정보	2013; 2013(1):
키워드	사구체여과율, 측정방법/ Glomerular filtration rate, Measurement method
초록	Background: Renal inulin clearance with continuous infusion method has been recognized as the gold standard for the measurement of glomerular filtration rate (GFR). However, inconvenience and complications associated with the method led to the development of alternative methods. In present study, we aimed to explore the relationships among three different methods for GFR measurement. Methods: Three different tests including renal inulin clearance with continuous infusion method (gold standard), systemic inulin clearance with a single injection method (standard protocol over 4 hours and extended protocol over 24 hours), and plasma 51Cr-EDTA clearance over 5 hours were performed in one subject to measure GFR. Total of 114 participants had all of three tests. We explored the correlation between methods and compared alternative methods to gold standard method. Results: There was a strong correlation between systemic inulin clearance and renal inulin clearance with a single injection method (γ=0.89, p<0.001), but renal inulin clearance overestimated systemic inulin clearance in overall. In addition, there was a very strong correlation between systemic inulin clearance measured by standard protocol over 4 hours and extended protocol over 24 hours (γ=0.99, p<0.001), and the difference between them was very small. The strong correlation between renal inulin clearance with continuous infusion method and systemic inulin clearance with single injection method (standard protocol) was observed (γ=0.89, p<0.001). The systemic inulin clearance (standard protocol) underestimated renal inulin clearance, in general (correlation coefficient: 0.89; slope: 0.64). Plasma 51Cr-EDTA clearance also had a very strong correlation with gold standard method (γ=0.92, p<0.001), and overestimated the renal inulin clearance on the whole (correlation coefficient: 0.92; slope: 0.81). Conclusion: Renal inulin clearance overestimated systemic inulin clearance using a single injection method, and the systemic inulin clearance using extended blood sampling protocol showed no significant difference compared to standard protocol in overall. Alternative methods for GFR measurement such as systemic inulin clearance with a single injection method and plasma 51Cr-EDTA clearance correlated well with gold standard, even though those alternatives somewhat underestimated and overestimated gold standard, respectively.
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