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논문분류	춘계학술대회 초록집
제목	NT-proBNP is a More Significant Prognostic Biomarker for Mortality than Troponin T in Incident Hemodialysis Patients
저자	Hyung Jung Oh1, Mi Jung Lee1, Chan Ho Kim1, Hyang Mo Koo1, Fa Mee Doh1,Jung Tak Park1, Seung Hyeok Han1, Tae-Hyun Yoo1, Yong-Lim Kim2, Yon Su Kim3, Chul Woo Yang4, Nam-Ho Kim5, Shin-Wook Kang1
출판정보	2013; 2013(1):
키워드	혈액투석, NT-proBNP, 사망인자/ NT-proBNP, Hemodialysis, Mortality
초록	Background: Numerous previous studies have demonstrated that cardiac and inflammatory biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or only measured one or two biomarkers. The aim of this study was to investigate the association between three cardiac biomarkers and mortality in incident hemodialysis patients. Methods: A prospective cohort of 864 incident hemodialysis patients was followed for up to 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patients were divided into ‘high’ and ‘low’ groups, and CV and all-cause mortality were compared between each group. Results: The CV survival rates were significantly lower in the ‘high’ NT-proBNP and cTnT groups compared to the corresponding ‘low’ groups, while there was no significant difference in CV survival rates between the two hsCRP groups. However, all-cause mortality rates were significantly higher in all three ‘high’ groups compared with each lower group. In multivariate Cox models, natural log of NT-proBNP and cTnT were found to be significant independent predictors of CV and all-cause mortality. Moreover, among the three biomarkers, NT-proBNP had the highest positive predictive values for not only CV mortality (AUC=0.812, P<0.001) but also all-cause mortality (AUC=0.666, p=0.003). Conclusions: Although high levels of NT-proBNP and cTnT, but not hsCRP, are independently associated with CV and all-cause mortality in incident hemodialysis patients, the prognostic value of NT-proBNP for mortality is higher than that of cTnT.
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