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논문분류 춘계학술대회 초록집
제목 Evaluation of Total Lymphocyte Count (TLC) and Subpopulation Lymphocyte Counts (SLCs) may be Helpful in Monitoring the Effectiveness of Nutrition in HD Patients
저자 You Jin Han, Sangeon Gwoo, Ye Na Kim, Ho Sik Shin, Yeon Soon Jung, Hark Rim
출판정보 2013; 2013(1):
키워드 림프구수, T림프구, B림프구, 혈액투석, 영양상태/Lymphocyte count, T B lymphocyte, HD, Nutritional status
초록 Background: Nutritional risk is one of the strongest predictors of morbidity and mortality in maintenance hemodialysis (HD) patients; thus, nutritional status evaluations and nutritional management are essential clinical procedures for managing these patients. In the present study, we evaluated correlations between total lymphocyte count (TLC) and subpopulation lymphocyte counts (SLCs) and nutritional status parameters in HD patients. Methods: This study was conducted in 50 stable HD patients with a mean age of 55.8±12.7 years. Their HD duration was 59.7±52.9 months. We collected clinical data such as sex, age, BMI, presence of diabetes mellitus, and laboratory results from the subjects’ charts. The SLCs were evaluated using flow cytometry. The analyses included CD3 cells (T lymphocytes), CD4 cells (helper lymphocytes), CD8 cells (cytotoxic suppressor lymphocytes), and CD19 cells (B lymphocytes). Correlation analyses were performed using the Spearman coefficient. p Values<0.05 were considered statistically significant. Results: TLC correlated positively with urea reduction ratio (URR), hemoglobin (Hb), and total iron-binding capacity (TIBC). CD 3 and CD 4 counts correlated positively with Hb, TIBC, and albumin but negatively with ferritin. CD 8 and CD 19 counts correlated positively with Kt/V and URR. We observed no correlations between TLC or SLCs and blood urea nitrogen, body mass index, or serum concentrations of calcium and cholesterol. Conclusion: Evaluation of TLC and SLCs may aid in monitoring the effectiveness of nutrition in HD patients.
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