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논문분류	춘계학술대회 초록집
제목	The Change of Circadian Rhythm of Blood Pressure after Kidney Transplantation
저자	Myung Hyun Lee, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park,Yong-Soo Kim, Chul Woo Yang
출판정보	2013; 2013(1):
키워드	일주기성 리듬, 혈압, 신장이식/Circadian rhythm, Blood pressure, Kidney transplantation
초록	Background: It is known that hypertension is well controlled with successful kidney transplantation (KT), but the effect of KT on circadian rhythm has not been fully investigated. The aim of this study is to investigate the change of circadian rhythm before and after KT. Methods: Forty-six patients took the ambulatory blood pressure monitoring (ABPM) before KT and 1 year after KT. According to the nocturnal reduction of systolic blood pressure (△SBP), we divided patients into dipper(△SBP ≥ 10%), non-dipper (0<△SBP ≤10%), and reverse dipper (SBP nocturnal rise). We investigated change of circadian rhythm both before KT and at 1 year after KT. We also evaluated the mean blood pressure, proportion of hypertensive patients and number of anti-hypertensive medication before and after KT. Results: Circadian rhythm before and after KT showed diverse pattern. Proportion of dipper, non-dipper and reverse dipper before KT was 15% (7/46), 59% (27/46) and 26% (12/46), respectively. After KT, proportion of three patterns was similar to those of pre KT. However, dippers were decreased from 15% (7/46) to 8% (4/46), and reverse dippers were increased from 26% (12/46) to 33% (15/46) at 1 year post-transplant. Mean blood pressure did not differ before and after KT (125±18/82±13 vs.121±10/81±9 mmHg, p>0.05) and proportion of hypertensive patients (with or without medications) also did not differ before and after KT (83%(38/46) vs 39% (18/46), p>0.05). But, number of anti-hypertensive medication was significantly decreased after KT (1.7±1.2 vs 0.6±0.9, p<0.05). Conclusions: The overall blood pressure improved, but abnormal circadian rhythm does not improve in most patients even after successful kidney transplantation.
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