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논문분류	춘계학술대회 초록집
제목	The Use of Plasma NGAL in Patients with Acute Kidney Injury
저자	Sang A Choi1, Eun Young Seong1, Harin Rhee1, Byeong Yun Yang1, Ihm Soo Kwak1,Woo Jin Jung1, Min Ji Shin1, Min Ja Paek2, Yun Ju Lee2, Gum Suk Jang2,Kyung Joo Park2, Sun Hye Kim2, Young Ji Yang3
출판정보	2013; 2013(1):
키워드	급성신손상, 신대체요법/NGAL, Acute kidney injury
초록	Background: Patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT) have high mortality and morbidity. Plasma NGAL is emerging as an excellent standard-alone troponin-like structural biomarker in the plasma and urine for the early diagnosis of AKI. The aim of this study was to evaluate the prognostic value of plasma NGAL on RRT requirement in adult patients with AKI. Methods: A total of 52 patients with AKI were analyzed for NGAL. Plasma NGAL at admission or nephrology consultation were measured by ELISA. AKI was diagnosed according to the RIFLE criteria and classified a causes of AKI : pre-renal, intrinsic, and post renal. Results: Mean plasma NGAL, serum creatinine, and estimating GFR (eGFR) according to the Modification of Diet in Renal Disease (MDRD) formula were 503.98 ng/ml, 3.66 mg/dl, and 24.21 mL•min-1 •1.73m-2. Mean plasma NGAL in R,I,F,L, and E group according to RIFLE criteria were 426.77 ng/ml, 503.78 ng/ml, 510.18 ng/ml, 664.43 ng/ml, and 673.67 ng/dl. Significant differences for NGAL level between the groups according to RIFLE criteria were not detected. Mean plasma NGAL in pre-renal, intrinsic, and post-renal were 478.91 ng/ml, 577.57 ng/ml, and 341 ng/ml. Plasma NGAL did not related with mortality, RRT requirement. Instead, NGAL/eGFR ratio were significantly higher in patients with than without RRT requirement. Conclusion: NGAL/eGFR was useful marker for predicting the RRT requirement in AKI.
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