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논문분류	춘계학술대회 초록집
제목	Paricalcitol Attenuates Gentamicin-induced Kidney Injury by Suppression of Apoptosis
저자	Sang Heon Suh1, Ko Eun Lee1, In Jin Kim2, Chang Seong Kim1, Joon Seok Choi1,Eun Hui Bae1, Seong Kwon Ma1, Jong Un Lee2, Soo Wan Kim1
출판정보	2013; 2013(1):
키워드	Apoptosis, GM, Paricalcitol
초록	Bacground: Beneficial effects of paricalcitol in gentamicin (GM)-induced kidney injury were previously reported. It is, however, not yet clear whether paricalcitol attenuates the apoptosis, which mainly contributes to the pathogenesis of GM-induced nephropathy. We investigated the effect of paricalcitol on apoptosis in rat kidneys after GM-induced injury. Methods: Three groups of rats were treated with vehicle, GM (150 mg/kg/day, i.m.) alone, or GM with paricalcitol (0.2 μg/kg/day, s.c.), respectively, for 7 days. Results: Plasma creatinine level was increased in GM treated rats, which was attenuated by paricalcitol co-treatment. TUNEL-positive cells increased in the kidney of GM treated, which was counteracted by paricalcitol co-treatment. Protein expression of Bax and cleaved form of caspase-3 was increased in the cortex/outer stripe of outer medulla from GM treated rats, while Bcl-2 expression decreased. These changes were attenuated by paricalcitol treatment. The phosphorylated JNK (Jun-N-terminal kinase) expression was increase in GM-treated rats, which was inhibited by paricalcitol. Conclusion: Paricalcitol treatment attenuates GM-induced nephropathy by suppressing the induction of apoptotic factors along with inhibition of JNK.
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