대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Impact of Clopidogrel on Clinical Outcomes in Acute Myocardial Infarction with Renal Dysfunction
저자	Chang Seong Kim, Joon Seok Choi, Eun Hui Bae, Seong Kwon Ma,Myung Ho Jeong, Soo Wan Kim
출판정보	2013; 2013(1):
키워드	Acute myocardial infarction, Major adverse cardiac events
초록	Background: Clopidogrel is an established treatment of acute myocardial infarction (AMI). However, renal dysfunction appears to be associated with reduced anti-platelet effects or increased bleeding risk of clopidogrel. We examined the impact of clopidogrel on clinical outcomes in patient with AMI according to the renal function. Methods: From November 2005 to September 2008, 13423 patients with AMI were enrolled in the prospective Korea Acute Myocardial Infarction Registry. The patients were divided into a group with clopidogrel (n=560) and a group without clopidogrel (n=12863). The primary endpoints were major adverse cardiac events (MACE) including a composite of all cause-of-death, myocardial infarction, target lesion revascularization, and coronary artery bypass graft during 1-year clinical follow-up. Results: In-hospital death and composite MACE at 1-month and 12-months were significantly increased associated with decreased estimated glomerular filtration rate (eGFR) regardless of taking clopidogrel. However, the clopidogrel group was significantly lower in hospital, short-term and long-term mortality throughout the eGFR compare with non-clopidogrel group. After adjusting for multiple covariates, the relative risks for 1-year mortality was lower in patients with clopidogrel therapy compared with non-clopidogrel therapy in eGFR of 45-59 and <45 ml/min/1.73m2 (hazard ratio [HR], 0.40; 95% confidence interval [CI], 0.19–0.82; p=0.013; and HR, 0.54; 95% CI, 0.30–0.97; p= 0.038, respectively), but not in eGFR >90 and 60-89 ml/min/1.73m2 (HR, 1.08; 95% CI, 0.11–10.98; p=0.945; and HR, 0.81; 95% CI, 0.32–2.06; p=0.657, respectively). Conclusions: Clopidogrel therapy in patients with AMI is associated with improved clinical outcomes and decreased the mortality, especially in decreased renal function.
원문(PDF)	PDF 원문보기

목록

위로가기