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제목	The Association of Blood Manganese Level with Diabetes and Renal Dysfunction
저자	Eun Sil Koh, Sungjin Chung, Hye Eun Yoon, Cheol Whee Park,Cheol Woo Yang, Yoon Sik Chang, Seok Joon Shin
출판정보	2013; 2013(1):
키워드	망간, 만성 신부전, 당뇨/Manganese, Diabetes, CKD
초록	Purpose: The purpose of this study was to evaluate the association between blood manganese level and the prevalence of chronic diseases in a Korean population. Methods: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES) analyzing the association between blood manganese level and the presence of chronic diseases. The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. In addition, these participants were evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. Results: Serum manganese level was significantly lower in the diabetes group than in the non-diabetes group (1.26± 0.02 vs. 1.35±0.01 μg/dL, respectively; p=0.001). The level of serum manganese was also significantly lower in the renal dysfunction group than in the group with normal renal function (1.28±0.03 vs. 1.35±0.01 μg/dL, respectively; p=0.036). There was no significant association with blood manganese level and the presence of ischemic heart disease and stroke. A multivariate logistic regression analysis that adjusted for age, sex, and body mass index was performed, and the odds ratio for diabetes was 0.652 (95% CI: 0.462-0.920) and was 0.589 (95% CI: 0.394- 0.881) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p=0.017). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p=0.015). Conclusion: The prevalence of diabetes and renal dysfunction was increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.
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