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논문분류	춘계학술대회 초록집
제목	Department of Internal Medicine Division of Nephrology, The Catholic University of Korea Seoul St. Mary
저자	Byung Ha Chung, Hyung Duk Kim, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
출판정보	2014; 2014(1):
키워드	신장이식, 혈액형 불일치, 고도감작
초록	Department of Internal Medicine Division of Nephrology, The Catholic University of Korea Seoul St. Mary In this study, we aimed to investigate to the impact of combined ABO incompatibility (ABOi) and highly sensitization (HS) to HLA on the clinical outcome of kidney transplantation (KT). We included 58 cases of kidney transplantation, which were ABO incompatible KT or showed highly sensitization (HS) to HLA or combination of both. The definition of highly sensitization was positivity of either type of crossmatch (XM) or presence of donor-specific anti-HLA antibody irrespective of the result of XM. We divided patient into 3 groups; ABOi group (n=26), ABOi-HS group (n=12) and HS group (n=20). Clinical outcomes in the 3 groups were compared. All patients took rituximab and plasmaphersis as desensitization therapy before KT. The number of pre-transplant plasmapheresis did not differ among three groups. After KT, development of acute rejection was higher in ABOi-HS or HS group compared to ABOi group (p<0.05, respectively). But it did not differ between ABOi-HS and HS group. The development of infection and infection free survival rate shows increasing or inferior tendency in ABOi-HS or HS group compared to ABO group as well (p=0.08 and 0.09 respectively). Development of post-operative bleeding did not differ among 3 groups. Allograft survival rate did not differ among 3 groups as well. This study shows that kidney transplantation across combined ABOi and HS shows acceptable clinical outcome and it was similar to that of solely highly sensitization group.
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