대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Impact of Partial Nephrectomy on Kidney Function in Patients with Renal Cell Carcinoma
저자	Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo wan Kim
출판정보	2014; 2014(1):
키워드	Nephrectomy, RCC, GFR
초록	Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea Introduction: This study aimed to compare the changes in kidney function and the association of tumor size and renal outcomes between patients with renal cell carcinoma (RCC) who underwent radical nephrectomy (RN) and those who underwent partial nephrectomy (PN). Methods: A retrospective cohort study was conducted for 557 patients [mean age, 61±12 years; baseline estimated glomerular filtration rate (eGFR), 82±17 mL/min/1.73m2] with an RCC ≤7 cm in diameter and normal contralateral kidney function who underwent PN or RN. PN was performed for 218 (39%) patients. Renal outcomes included the incidence of acute kidney injury (AKI), new-onset chronic kidney disease (CKD, an eGFR <60 mL/min/1.73m2 3 months after the operation), and a ≥25% decline in eGFR 1 year after surgery. Results: Serial changes in eGFR were compared during the 3 years of follow-up. Postoperative eGFR was significantly lower in patients undergoing RN than in those undergoing PN. The incidence of AKI and new-onset CKD was significantly higher in patients after RN (70.1% vs. 24.3%, respectively; p<0.001) than after PN (55.7% vs. 6.2%, respectively; p<0.001). According to the multivariable logistic regression analysis, RN was an independent risk factor for a ≥25% decline in kidney function after 1 year regardless of the tumor size, even after adjusting for various covariates (i.e., tumor size ≤4 cm, odds ratio [OR]=31.9, 95% confidence interval [CI]=15.5-65.5; and 4 cm
원문(PDF)	PDF 원문보기

목록

위로가기