| 저자 |
Hyo Jin Kim, Jin Suk Han, Hajeong Lee, Dong Ki Kim,Kwon Wook Joo, Yon Su Kim, Curie Ahn, Kook-Hwan Oh |
| 초록 |
Background: It is speculated that a lower education level is a risk factor for higher peritoneal dialysis (PD)-associated peritonitis, potentially resulting in technique failure. We have analyzed the influence of lower education level on the development of peritonitis, technique failure and overall patient mortality.
Methods: This is a single-center, retrospective cohort study. Subjects who started PD at Seoul National University Hospital between Jan, 2000 and Dec, 2012 were enrolled. Subjects were divided into three groups; lower (academic year ≤9 years, n=102), intermediate (9< academic year ≤12 years, n=229), and higher (academic year >12 years, n= 324) education groups. Cox proportional hazard model was employed to analyze the influence of the education level on the development of peritonitis, technique failure and all-cause mortality.
Results: A total of 655 incident PD patients (61% male, age 48±14 years) were analyzed. Mean duration of follow-up was 42.8±32.8 months. Cumulative patient survival at 5 and 10 years were 86% and 68%, respectively. During follow-up, 248 subjects (38.2%) experienced more than one episode of peritonitis, 142 subjects (21.7%) underwent technique failure and 69 subjects (10.5%) died. After adjustment to the age, sex, diabetes, other comorbidities, visual disturbance, CRP, albumin, GFR, lower education level was shown to be an independent risk factor for both peritonitis [hazard ratio (HR): 1.60; 95% confidence interval (CI): 1.09-2.35] and technique failure [HR 1.74; 95% CI 1.04- 2.89]. However, lower education level was not associated with increased overall mortality [HR 1.49, 95% CI 0.71- 3.15].
Conclusion: Although lower education level was a significant risk factor for peritonitis and technique failure, it was not associated with increased mortality in PD patients. Subjects with lower education level should not be discouraged against choosing PD as their first-line renal replacement therapy. Comprehensive training in PD exchange procedures and multidisciplinary education is warranted for overcoming the lower education level in subjects undergoing PD therapy. |