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논문분류	춘계학술대회 초록집
제목	Effect of Hepatitis B and C Virus Infections on Mortality in the Korean Dialysis Patients: a Prospective Multicenter Cohort Study
저자	Eugene Kwon1, Jang-Hee Cho1, Hye Min Jang2, Yon Su Kim3, Shin-Wook Kang4,Hee-Yeon Jung1, Ji-Young Choi1, Sun-Hee Park1, Chan-Duck Kim1, Yong-Lim Kim1
출판정보	2014; 2014(1):
키워드	B형 간염, C형 간염, 투석, 생존율
초록	Background: The role of HBV and HCV infections in survival among dialysis patients remains incompletely understood. This study investigated the prevalence of hepatitis B or C infection and its impact on survival in Korean patients on maintenance dialysis. Methods: The study included 3,321 maintenance dialysis patients who underwent hepatitis B antigen (HBsAg) and HCV antibody (Ab) testing from a multicenter prospective cohort study in Korea. HBsAg-positive and HCV Ab-positive patients were matched to hepatitis virus-negative patients using propensity score by a ratio of one to two. We compared the survival of HBsAg and HCV Ab-positive patients to that of hepatitis virus-negative patients. Results: A total of 221 (6.7%) HBsAg-positive and 108 (3.7%) HCV Ab-positive patients were enrolled and followed up for mean 23.5±13.3 months. Patients with dialysis vintage of ≥10 years showed a significantly higher prevalence of HBV and HCV than patients with dialysis vintage of <1 year (HBV 10.2% vs. 5.6%, p=0.011 and HCV 7.5% vs. 3.3%, p=0.003, respectively). After propensity score matching, the cumulative survival was not different between HBsAg-positive and hepatitis virus-negative patients (p=0.370). However, HCV Ab-positive patients showed a significantly lower survival than hepatitis virus-negative patients (p= 0.026). Conclusions: The prevalence of HBV and HCV increases with the time on dialysis. HCV infection in maintenance dialysis patients is associated with an increased risk of mortality.
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