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논문분류	춘계학술대회 초록집
제목	Prevalence and Risk Factors for Anemia in Chronic Kidney Disease in Korea - KNOW-CKD Cohort Study
저자	Hye Jin Lim1, Young-Hwan Hwang2, Woo-kyung Chung1, Su-Ah Sung2,Kook-Hwan Oh3, Dong-Wan Chae4, Gyuhun Choi5, Kyubeck Lee6,Yong Soo Kim7, Soo Wan Kim8, Young Hoon Kim9, Joongyub Lee10, Sue Kyung Park10, Curie Ahn3
출판정보	2014; 2014(1):
키워드	빈혈, 만성콩팥병, 철분 결핍
초록	Background: Anemia is common in patients with chronic kidney disease (CKD) and may contribute to adverse clinical outcomes. Early identification and treatment of anemia may improve cardiovascular morbidity and mortality, but few reports are available on the large-scale population data in Korean patients with CKD. The aim was to examine the prevalence of anemia and the risk factors for anemia in CKD. Methods : We investigated the prevalence and risk factors in CKD stage 1-5 (non-dialysis) patients in Korea based on the baseline data obtained from a prospective cohort study (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease (KNOW-CKD)). Anemia was defined as hemoglobin <13 g/dL in male and <12 g/dL in female. Iron deficiency was defined when transferrin saturation (TSAT) was <20% or ferritin level <100 ng/mL. Results: A total of 1,472 subjects at baseline had hemoglobin levels measured. Anemia was present in 41% in male and 51% in female of all patients. Prevalence of anemia increased as GFR and albuminuria stage progressed. Diabetic patients had signifinicantly higher prevalence of anemia than subjects with other etiologies. Risk factors for anemia include female (OR=1.7), diabetic nephropathy (OR=5.0), lower GFR (OR=4.6, 6.6, 23.7, and >100 at stage 3a, 3b, 4, and 5, respectively), TSAT <20% (OR=3), and overt albuminuria (OR=1.9). Ferritin level was not associated with anemia. Conclusion: The prevalence of anemia increases as GFR lowers and albuminuria increases. Female gender, diabetes, lower GFR, low TSAT and albuminuria are independent risk factors for anemia. Further defining the mechanism may provide ways to optimize outcomes in anemia management.
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